Helicobacter pylori (Hp) is a type of bacteria that causes gram-negative, spiral-shaped, motile, flagellated epithelial damage that can lead to gastrointestinal disorders, gastritis, peptic ulcer, andgastric malignancies. The diagnosis of this microorganism, which has infected almost half of the world's population, is important. Among the diagnostic methods, non-invasive methods include urea breath test and serological examinations, while bacteria should be demonstrated in the final diagnosis in endoscopic biopsy and eradication therapy should be performed after diagnosis. Cases should be re-evaluated by biopsy in case of failure to eradicate due to reinfection or inadequate treatment. In this article, it is aimed to create a summary source by defining histopathological diagnosis methods of gastric biopsies used in Hp diagnosis.