In this letter to Şahin et al.'s article titled "Assessment of Relationship Between Health Literacy and Level of Knowledge on Prenatal Diagnosis and Antenatal Care in Pregnant Women," the authors critically evaluate some aspects of the study methodology. In particular, the study's single-center design and the sample's homogeneous structure in terms of socioeconomic and educational levels limit the generalizability of the findings. It is also emphasized that more information should be provided on the psychometric properties of the health literacy scale and that longitudinal studies should be designed to investigate causality.