Introduction: The primary aim of this study was to provide evidence-based insights to inform public health nursing practice regarding contemporary interventions designed to prevent vaccine hesitancy.
Methods: This study conducted a comprehensive examination of all trials related to vaccine hesitancy registered on ClinicalTrials.gov up to March 2, 2025. The 123 identified trials underwent systematic summarization based on critical characteristics, encompassing study status, study phase, study type, funding source, and the methodological approaches utilized to address vaccine hesitancy. Quantitative data about the characteristics of the included trials were analyzed using the JAMOVI statistical software package.
Results: A significant proportion of the identified studies, 52.0% (n=64), had reached completion, with results from 10.4% (n=13) of the total cohort accessible within the system. The majority of the trials, 81.6% (n=100), were classified as intervention studies, with initiation dates spanning from April 2010 to March 2025. The six trials originated from Türkiye. Of these, one study (20.0%) has been completed, the status of another (20.0%) is currently unknown, two (40.0%) are in the " Enrolling by invitation " phase, and two (20.0%) is actively recruiting participants. The review further indicated a substantial focus on experimental interventions aimed at mitigating vaccine hesitancy specifically related to the COVID-19 vaccine (n=60, 48.8%).
Discussion and Conclusion: The predominant intervention strategy under consideration incorporated behavioral techniques, specifically the dissemination of informational and reminder messages via Short Message Service (SMS) alongside the provision of didactic training. Following SMS-based interventions, motivational interviewing emerged as the next most common intervention approach.
Keywords: Anti-vaccine movement; Clinical trial; Public health nursing; Vaccine hesitancy
, Bersu Adal1 
