Investigation of the Relationship Between Left Ventricular Hypertrophy and Endothelial Dysfunction in Patients with Primary Hypertension by ADMA and hsCRP

Introduction: Hypertension affects many organs in the target. This study investigates left ventricular hypertrophy (LVH), which can cause conduction disorders, arrhythmias, and heart failure. Endothelial dysfunction (ED) was evaluated using serum asymmetric dimethyl-arginine (ADMA) levels.
Method: The study included a total of 90 voluntary participants, consisting of 30 patients with hypertension and left ventricular hypertrophy, 30 hypertensive patients without hypertrophy, and 30 normotensive healthy controls. Serum ADMA levels were used to detect endothelial dysfunction.
Results: The results showed that serum ADMA levels were significantly higher in the patient group compared to the control group. However, there was no significant difference in serum asymmetric dimethylarginine (ADMA) levels between the two subgroups of patients, with or without left ventricular hypertrophy (LVH). A correlation analysis was performed, and no correlation was found between serum ADMA levels and LV mass index (LVMI).
Discussion and Conclusion: There appears to be no direct relationship between LVH and endothelial dysfunction. Furthermore, it can be noted that inflammatory processes contribute to the development of left ventricular hypertrophy (LVH) rather than endothelial dysfunction (ED). The duration of exposure to high blood pressure and the stage of hypertension are also believed to have an impact on this process.

Keywords: Hypertension, hypertrophy, left ventricular hypertrophy, inflammation