Relationship Between Preoperative Complete Blood Count Parameters and Clinicopathological Features in Endometrioid Type Endometrium Cancer Patients

Introduction: Complete blood count parameters have been studied as markers since they are associated with the inflammatory process in the diagnosis and prognosis of many types of cancer. This study aimed to evaluate the preoperative complete blood count parameters in patients with and without endometrioid type endometrial cancer while investigating the relationship of these biomarkers with prognostic factors in the cancer group.
Methods: The study had a retrospective design. All the patients with endometrial cancer were of the endometrioid type. The cancer group consisted of 94 pathologically confirmed cases. The control group consisted of 96 women diagnosed with dysfunctional uterine bleeding without any signs of organic gynecological pathology. The clinicopathological features and preoperative complete blood count results of all the patients were evaluated.
Results: Hemoglobin, leucocyte and platelet measurements were higher; whereas lymphocytes, monocytes, mean platelet volume were lower in the cancer group as compared with the controls (p<0.05). When subjects with endometrial cancer were evaluated on their own; monocyte/lymphocyte ratio was higher in the patients with lymph node metastasis as compared with early stage cases (p=0.006). Age remained the only factor in predictive of prognostic factors such as myometrial invasion depth, lymph node metastases, advanced stage, and grade.
Discussion and Conclusion: Complete blood count parameters can be simple, easily available and inexpensive markers in endometrial cancer. In addition, rising monocyte/lymphocyte ratios may be guiding in the prediction of advanced disease. However, molecular studies that specifically investigate the expression of secretory factors are needed for the actual predictive potential of these biomarkers.

Keywords: Blood count; endometrial cancer; grade; prognose; stage